The Histamine Connection To Neuropsychiatry 

Histamine is a naturally occurring compound that plays a crucial role in immune responses, neurotransmission, and regulation of stomach acid. While histamine is essential for many physiological processes, an imbalance in histamine levels can have significant implications for both neuropsychiatric conditions and immune health.

Histamine and Neuropsychiatric Conditions:

Histamine is involved in neurotransmission in the brain and can affect mood, behavior, and cognitive function. An imbalance in histamine levels has been linked to various neuropsychiatric conditions, including:

  1. Anxiety and Depression: Histamine acts as an excitatory neurotransmitter in the brain, and an excess of histamine can lead to increased anxiety and depressive symptoms.

  2. Attention Deficit Hyperactivity Disorder (ADHD): Histamine plays a role in the regulation of attention and hyperactivity. High histamine levels have been associated with ADHD symptoms, including difficulty focusing and impulsivity.

  3. Autism Spectrum Disorder (ASD): Studies have shown that histamine dysregulation may contribute to the development of ASD. Elevated histamine levels have been observed in individuals with ASD, and antihistamine medications have shown promise in reducing certain symptoms.

  4. Sleep Disorders: Histamine is involved in the regulation of the sleep-wake cycle, and an imbalance in histamine levels can disrupt sleep patterns, leading to conditions such as insomnia and sleep apnea.


Histamine and Immune Health

Histamine is a key mediator of the immune response, and an imbalance in histamine levels can impact immune health.

Symptoms of high histamine can include:

  1. Allergies: Histamine is released in response to allergens and triggers symptoms such as itching, sneezing, runny nose, and hives.

  2. Inflammatory Bowel Disease (IBD): Histamine has been implicated in the development of IBD, including conditions like Crohn's disease and ulcerative colitis. High histamine levels can contribute to gut inflammation and worsen IBD symptoms.

  3. Mast Cell Activation Syndrome (MCAS): MCAS is a condition characterized by an overactive response of mast cells, leading to excessive histamine release and resulting in symptoms like flushing, itching, hives, and gastrointestinal issues.

  4. Multiple Chemical Sensitivity (MCS): High histamine levels can contribute to MCS, a condition where individuals have heightened sensitivity to various environmental triggers, leading to symptoms like headaches, fatigue, and brain fog.

Symptoms of high histamine can vary greatly among individuals and may present differently in different conditions. Common symptoms may include headaches, fatigue, brain fog, digestive issues, skin rashes, mood changes, and respiratory symptoms.

Managing Histamine

If you suspect that histamine imbalances may be contributing to neuropsychiatric conditions or immune health issues, it's important to work with a healthcare professional for proper diagnosis and management.

Low-Histamine Diet


Avoiding or reducing histamine-rich foods, such as aged cheeses, processed meats, alcohol, and fermented foods, may help in managing symptoms.



 Some supplements, such as vitamin B6 and vitamin C, may help support histamine metabolism and reduce histamine levels.

Lifestyle Changes


Managing stress, improving gut health, and reducing exposure to environmental triggers may also be beneficial in managing histamine imbalances.

Histamine is a complex compound that plays a significant role in both neuropsychiatric conditions and immune health. High histamine levels can contribute to a range of symptoms and conditions, and proper diagnosis and management are crucial. Working with a healthcare professional to identify and address histamine imbalances through dietary changes, medication, supplements, and lifestyle modifications can be beneficial in managing symptoms associated with high histamine levels.

It's also important to note that everyone's histamine tolerance and triggers may vary, and what works for one person may not work for another. Keeping a symptom diary and tracking your food intake, environmental exposures, and symptoms can help identify individual triggers and guide personalized treatment plans.

In addition to managing histamine imbalances, it's essential to address the underlying factors contributing to histamine dysregulation. This may include addressing gut health, reducing stress, optimizing nutrition, and managing other underlying health conditions.

In conclusion, histamine imbalances can impact both neuropsychiatric conditions and immune health. Understanding the link between histamine and these conditions, recognizing the symptoms of high histamine, and working with a healthcare professional to develop a personalized treatment plan can help manage symptoms and improve overall health and well-being. Remember, you are not alone, and there is support available to help you on your journey towards better histamine balance and improved health. 

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Histamine- Dr. Melanie Garrett, ND . Naturopathic Doctor, Fort McMurray Alberta.

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*This does not substitute medical advice or consultation. Please speak with your health care provider before testing.

Medical Disclaimer:

The information provided in this content is solely for informational and educational purposes. It should not be considered a substitute for medical advice or treatment from a personal physician. It is strongly recommended that all readers/viewers of this content consult their doctors or qualified health professionals for any specific health inquiries. Dr. Garrett, ND and the publisher of this content do not assume responsibility for any potential health implications resulting from individuals reading or implementing the information provided in this educational content. It is especially important for viewers of this content, particularly those taking prescription or over-the-counter medications, to consult their physicians prior to initiating any nutrition, supplement, or lifestyle program.